Rising opioid prescribing in adult US emergency department visits: 2001–2010
M Mazer‐Amirshahi, PM Mullins… - Academic …, 2014 - Wiley Online Library
Objectives The objective was to describe trends in opioid and nonopioid analgesia
prescribing for adults in US emergency departments (ED s) over the past decade. Methods …
prescribing for adults in US emergency departments (ED s) over the past decade. Methods …
[HTML][HTML] Pharmacogenomic biomarkers for improved drug therapy—recent progress and future developments
Much of the inter-individual variability in drug efficacy and risk of adverse reactions is due to
polymorphisms in genes encoding proteins involved in drug pharmacokinetics and …
polymorphisms in genes encoding proteins involved in drug pharmacokinetics and …
A 2013 updated systematic review & meta‐analysis of 36 randomized controlled trials; no apparent effects of non steroidal anti‐inflammatory agents on the risk of …
L Riggin, J Ramakrishna, DD Sommer… - Clinical …, 2013 - Wiley Online Library
Background Although the literature suggests that non‐steroidal anti‐inflammatory drugs
(NSAID s) are effective in controlling post‐operative pain in the paediatric population …
(NSAID s) are effective in controlling post‐operative pain in the paediatric population …
Opioids: a review of pharmacokinetics and pharmacodynamics in neonates, infants, and children
JC Thigpen, BL Odle, S Harirforoosh - European Journal of Drug …, 2019 - Springer
Pain management in the pediatric population is complex for many reasons. Mild pain is
usually managed quite well with oral acetaminophen or ibuprofen. Situations involving more …
usually managed quite well with oral acetaminophen or ibuprofen. Situations involving more …
Death or neurologic injury after tonsillectomy in children with a focus on obstructive sleep apnea: Houston, we have a problem!
CJ Coté, KL Posner, KB Domino - Anesthesia & Analgesia, 2014 - journals.lww.com
BACKGROUND: Obesity is epidemic in the United States and with it comes an increased
incidence of obstructive sleep apnea (OSA). Evidence regarding opioid sensitivity as well as …
incidence of obstructive sleep apnea (OSA). Evidence regarding opioid sensitivity as well as …
[HTML][HTML] Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine …
MV Tzvetkov, JN dos Santos Pereira, I Meineke… - Biochemical …, 2013 - Elsevier
We investigated whether morphine and its pro-drug codeine are substrates of the highly
genetically polymorphic organic cation transporter OCT1 and whether OCT1 polymorphisms …
genetically polymorphic organic cation transporter OCT1 and whether OCT1 polymorphisms …
Cytochrome P450-activated prodrugs
PR Ortiz de Montellano - Future medicinal chemistry, 2013 - Future Science
A prodrug is a compound that has negligible, or lower, activity against a specified
pharmacological target than one of its major metabolites. Prodrugs can be used to improve …
pharmacological target than one of its major metabolites. Prodrugs can be used to improve …
Pharmacogenetics: a general review on progress to date
AK Daly - British medical bulletin, 2017 - academic.oup.com
Background Pharmacogenetics is not a new subject area but its relevance to drug
prescribing has become clearer in recent years due to developments in gene cloning and …
prescribing has become clearer in recent years due to developments in gene cloning and …
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone)
M Matic, M Nijenhuis, B Soree… - European Journal of …, 2022 - nature.com
Abstract The current Dutch Pharmacogenetics Working Group (DPWG) guideline, describes
the gene–drug interaction between CYP2D6 and the opioids codeine, tramadol and …
the gene–drug interaction between CYP2D6 and the opioids codeine, tramadol and …