Objective In recent years, there has been increased emphasis on treating pain in emergency
departments (EDs), coinciding with mounting concerns regarding the abuse potential of …

Background. Pain management for children with musculoskeletal injuries is suboptimal and,
in the absence of clear evidence‐based guidelines, varies significantly. Objective. To …

Pharmacogenomics is a study of how the genome background is associated with drug
resistance and how therapy strategy can be modified for a certain person to achieve benefit …

Most of the prescribing and dispensing of medicines happens in primary care.
Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation …

Inadequate pain relief and adverse effects from analgesics remain common in children and
adults during the perioperative period. Opioids are the most commonly used analgesics in …

Opioid-related respiratory depression (RD) is a serious clinical problem as it causes multiple
deaths and anoxic brain injuries. Morphine is subject to efflux via P-glycoprotein transporter …

New Evidence about an Old Drug — Risk with Codeine after Adenotonsillectomy | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

The vast range of genetic diversity contributes to a wonderful array of human traits and
characteristics. Unfortunately, a consequence of this genetic diversity is large variability in …

Importance Ibuprofen is an effective analgesic after tonsillectomy alone or tonsillectomy with
adenoidectomy, but concerns remain about whether it increases postoperative hemorrhage …

After postoperative deaths in children who were prescribed codeine, several pediatric
hospitals have removed it from their formularies. These deaths were attributed to atypical …