Omics data integration is becoming necessary to investigate the genomic mechanisms
involved in complex diseases. During the integration process, many challenges arise such …

Non-targeted metabolomics constitutes a part of the systems biology and aims at
determining numerous metabolites in complex biological samples. Datasets obtained in the …

Bladder cancer is a common malignant urinary tumor with a high rate of recurrence and
quick progression, which threats human health. With the research on bladder cancer …

Background Bladder cancer (BC) is the 10th most frequent tumor worldwide. Evidence
shows an association between elevated risk of BC and various single nucleotide …

Arterial stiffening is a hallmark of early vascular aging (EVA) syndrome and an independent
predictor of cardiovascular morbidity and mortality. In this case-control study we sought to …

Abstract Analysis of microarray data is associated with the methodological problems of high
dimension and small sample size. Various methods have been used for variable selection in …

Background Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed in late
adulthood; therefore, many patients suffer or have suffered from other diseases. Identifying …

Background: Various studies had explored the relationship between TP53 codon 72
polymorphisms and the risk of bladder cancer (BC). However, their results remained …

Simple Summary Methods used for the identification of hereditary cancer genes have
evolved in parallel to technological progress; however, much of the genetic predisposition to …

Genetic predisposition to cutaneous malignant melanoma (CMM) involves highly penetrant
predisposing genes and low and intermediate penetrant predisposing alleles. However, the …