Helper T cells coordinate immune responses through the production of cytokines. Th2 cells
express the closely linked Il4, Il13, and Il5 cytokine genes, whereas these same genes are …

Antigen and cytokine receptor signals act in synergy to direct the differentiation of CD4+ T
cells. These signals initiate reciprocal activation and silencing of the interferon-γ (IFN-γ) and …

Antisense Noncoding RNA in the INK4 Locus (ANRIL) is the prime candidate gene at
Chr9p21, the well-defined genetic risk locus associated with multiple human diseases …

The structurally and functionally related interleukin‐4 (IL‐4) and IL‐13 cytokines play pivotal
roles in shaping immune activity. The IL‐4/IL‐13 axis is best known for its critical role in T …

Substantial experimental evidence now supports the notion that allergic diseases are
characterised by a skewing of the immune system towards a T-helper cell type-2 (Th2) …

Abstract Interleukin-4 (IL-4) is crucial for the differentiation of naive T helper (TH) cells into
the TH2 effector cells that promote humoral (antibody) immunity and provide protection …

Abstract The transcription repressor Yin Yang 1 (YY1) is expressed in several human cancer
cell lines and its expression correlates with resistance to immune-mediated apoptosis. This …

IL-4 was first identified as a T cell-derived growth factor for B cells. Studies over the past
several decades have markedly expanded our understanding of its cellular sources and …

The severity of Hashimoto's disease (HD) and intractability (or inducibility to remission) of
Graves' disease (GD) varies among patients. Forkhead box P3 (FoxP3) is a crucial …

BRD4 is a well‐recognized transcriptional activator, but how it regulates gene transcriptional
repression in a cell type‐specific manner has remained elusive. In this study, we report that …