Mycobacterium tuberculosis (M. tb) is the etiological agent of pulmonary tuberculosis (TB);
this disease remains a worldwide health problem. Yin-Yang-1 (YY1) plays a major role in …

Interleukin-4 (IL-4) is a glycoprotein of approximate molecular mass 15 kDa. Mouse IL-4
cDNA was first isolated from a T helper 2 (TH2) cell library as a cDNA encoding a unique …

Abstract Interleukin (IL)-4 acts on T cells as a growth and activation factor, and promotes the
differentiation of type 2 T helper cells. In T cells, expression of the gene encoding IL-4 is …

Spontaneous diabetes in B (io) B (reeding) rats is complex, polygenic, and recessively
inherited. Several crossing studies have demonstrated that beside the class II genes of the …

Summary Although interleukin 13 (IL‐13) is an important mediator of asthma and allergic
diseases, the molecular mechanisms regulating IL‐13 gene expression are not well …

Abstract The Polycomb/Trithorax Responsive Elements (PRE/TREs) are the cis-regulatory
sequences that interact with both repressive (PcG) as well as activating (TrxG) complexes …

Three frequent genetic polymorphisms in the human high-affinity IgE receptor α-subunit
(FcεRIα) were shown to be associated with allergic disorders and/or total serum IgE levels in …

The ID (inhibitor of differentiation or DNA binding) helix–loop–helix proteins are important
mediators of cellular differentiation and proliferation in a variety of cell types through …

During the twentieth century the gene emerged as the major driving force of biology. Initially,
even the nature and behavior of gene vehicles, the chromosomes, were subjected to doubts …

Chronic obstructive pulmonary disease (COPD) and bronchial asthma (BA) are 2 severe
respiratory disorders with different predominated immunopathologies. There are several …