There is no standard definition for trauma-induced coagulopathy (TIC). However, it could be
defined as an abnormal hemostatic response secondary to trauma. The terms “early TIC” …

Tissue engineering has a great application prospect as an effective treatment for tissue and
organ injury, functional reduction, or loss. Bioactive tissues are reconstructed and damaged …

Background: Haemorrhage is a major cause of death in severe trauma. Fibrinogen plays a
critical role in maintaining haemostasis in traumatic haemorrhage, and early replacement …

With transfusion ongoing, the patient was rushed to the operating room (OR) for a
thoracotomy to determine the source of bleeding where arterial and central access was …

Background The prevalence of diabetic microvascular diseases has increased significantly
worldwide, the most common of which are diabetic nephropathy (DN) and diabetic …

Introduction Acute hemorrhage is a global healthcare issue, and remains the leading
preventable cause of death in trauma. Acute severe hemorrhage can be related to traumatic …

Complementopathy, endotheliopathy, and coagulopathy following a traumatic injury are key
pathophysiological mechanisms potentially associated with multiple-organ failure (MOF) …

Purpose Trauma is a leading cause of mortality, with major bleeding and trauma-induced
coagulopathy (TIC) contributing to negative patient outcomes. Treatments for TIC include …

Intravenously infusible nanoparticles to control bleeding have shown promise in rodents, but
translation into preclinical models has been challenging as many of these nanoparticle …

Current trauma-induced coagulopathy resuscitation protocols use slow laboratory
measurements, rules-of-thumb, and clinician gestalt to administer large volumes of …