Nose-to-brain drug delivery has been of great interest for the treatment of many central
nervous system (CNS) diseases and psychiatric disorders over past decades. Several …

Mesenchymal stem cells (MSCs) are becoming hotspots for application in disease therapies
recently, combining with biomaterials and drug delivery system. A major advantage of MSCs …

Alzheimer's disease (AD) is a central neurodegenerative disorder characterized by
behavioral disturbance and progressive cognitive impairment, and it is common in pre …

Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain
barrier and systemic adverse effects. Intranasal administration offers a direct route to the …

Huntington's disease (HD) is a neurological disorder characterized by a reduction in
medium-spiny neurons in the brain. Currently, there is no cure for HD and treatment relies …

The blood-brain barrier (BBB) is a membrane barrier considered one of the most crucial
protective architectures in the central nervous system (CNS). Its presence acts as a hurdle …

The design, synthesis and characterization of a novel nucleoamino acid derivative based on
an l-tryptophanamide functionalised with a thymine nucleobase (named TrpT) is here …

Nanoparticles are designed to entrap drugs at a high concentration, escape clearance by
the immune system, be selectively taken up by cancer cells, and release bioactives in a rate …

In severe cases, Parkinson's disease causes uncontrolled movements known as motor
symptoms such as dystonia, rigidity, bradykinesia, and tremors. Parkinson's disease also …

With respect to the Parkinson's disease (PD), herein, we aimed at synthetizing and
characterizing two novel macromolecular conjugates where dopamine (DA) was linked to N …