All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …

The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …

Abstract Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare disorder of
striking complexity. It arises from somatic, gain-of-function mutations in GNAS, leading to …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

McCune-Albright syndrome (MAS) is a rare, mosaic disorder presenting along a broad
clinical spectrum. Disease arises from somatic-activating GNAS mutations, leading to …

Purpose To describe the uptake of 68 Gallium-labelled fibroblast activation protein inhibitor
(68 Ga-FAPI) in the bones and joints for better understanding of the role of 68 Ga-FAPI PET …

Fibrous dysplasia (FD) is a rare, non-hereditary skeletal disorder characterized by its chronic
course of non-neoplastic fibrous tissue buildup in place of healthy bone. A myriad of factors …

Fibrous dysplasia is an uncommon genetic disorder in which bone is replaced by immature
bone and fibrous tissue, manifesting as slow-growing lesions. Sporadic post-zygotic …

For patients diagnosed with a rare musculoskeletal or neuromuscular disease, pain may
transition from acute to chronic; the latter yielding additional challenges for both patients and …

Introduction Fibrous dysplasia of bone (FD) is a rare congenital bone disease, due to a
somatic mutation of GNAS. This mutation results in a defect of osteoblast differentiation and …