Simple Summary Pain associated with cancer diagnoses is a serious concern and one of
the most common symptoms reported by cancer patients. The insufficient relief of cancer …

Novel drugs, drug sequences and combinations have improved the outcome of prostate
cancer in recent years. The latest approvals include abiraterone acetate, enzalutamide and …

Despite many recent advances in the therapy for metastatic castration-resistant prostate
cancer (mCRPC), the disease remains incurable, although men suffering from this disease …

Simple Summary The ubiquitin proteasome system (UPS) governs the non-lysosomal
degradation of oxidized, damaged, or misfolded proteins in eukaryotic cells. Dysregulation …

Background. In this paper, we provide background and context regarding the potential for a
new data-sharing platform, the Project Data Sphere (PDS) initiative, funded by financial and …

A central question in the assessment of benefit/harm of new treatments is: how does the
average outcome on the new treatment (the factual) compare to the average outcome had …

Prostate cancer (PC) is one of the most common cancers in males and the fifth leading
reason of death. Age, ethnicity, family history, and genetic defects are major factors that …

Background: Lacking head-to-head trial, the optimal treatment for patients with metastatic
castration-resistant prostate cancer (mCRPC) after docetaxel failure is unclear. This study is …

Introduction Hypoxia-inducible factor (HIF) mediates multiple intracellular processes that
drive cellular metabolism and induce proliferation. Dysregulated HIF expression is …

There have been immediate and profound impacts of SARS-CoV-2 and COVID-19 on health
care services worldwide, with major consequences for non COVID-19 related health care …