The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the
reverse-transcribed viral DNA into the host chromosome. This function of IN has been well …

Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral
agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we …

Human immunodeficiency virus type 1 (HIV-1) integrase (IN) integrates viral DNA into the
host genome using its 3′-end processing and strand-transfer activities. Due to the …

The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral
RNA and is highly conserved among many strains of the virus. It forms a conical structure by …

ABSTRACT The retroviral Gag capsid (Gag-CA) interdomain linker is an unstructured
peptide segment connecting structured N-terminal and C-terminal domains. Although the …

Reverse transcriptase (RT) and integrase (IN) are encoded tandemly in the pol genes of
retroviruses. We reported recently that HIV-1 RT and IN need to be supplied as the pol …

Background Antiretroviral therapy (ART) can mitigate the morbidity and mortality caused by
the human immunodeficiency virus (HIV). Successful development of ART can be …

Human immunodeficiency virus type 1 (HIV-1) uptakes homo-dimerized viral RNA genome
into its own particle. A cis-acting viral RNA segment responsible for this event, termed …

Sapovirus (SaV) is a nonenveloped RNA virus that causes acute gastroenteritis in humans.
Although SaV is a clinically important pathogen in children, an effective vaccine is currently …

Thermoplasma trehalase Tvn1315 is predicted to be composed of a β-sandwich domain
(BD) and a catalytic domain (CD) based on the structure of the bacterial GH15 family …