Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

The antibacterial agents currently in clinical development are predominantly derivatives of
well-established antibiotic classes and were selected to address the class-specific …

The increasing prevalence of antibiotic resistance is a threat to human health, particularly
within vulnerable populations in the hospital and acute care settings. This leads to …

Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

Iron is an essential element for all microorganisms. Siderophores are low-weight, high-
affinity iron chelating molecules produced in response to iron deficiency by Gram-positive …

Antibiotic resistance is a global health issue and a potential risk for society. Antibiotics
administered through conventional formulations are devoid of targeting effect and often …

Antibiotic therapy is the most powerful strategy for treating bacterial infections in clinic.
However, antibiotic resistance has become one of the biggest threats to public health …

To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization
to ensure sufficient supply and to avoid toxic excess of this essential trace element. As …

The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an
extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These …