The advent of cefiderocol provides hope for the clinical treatment of multi-drug resistant
gram-negative bacteria (GNB), especially those with carbapenem resistance. Resistance of …

Inspired by natural sideromycins, the conjugation of antibiotics to siderophores is an
attractive strategy to facilitate “Trojan horse” delivery of antibiotics into bacteria. Genome …

Oxazolidinones represent a significant class of synthetic bacterial protein synthesis
inhibitors that are primarily effective against Gram-positive bacteria. The commercial …

Background: Siderophores are small-molecule iron-chelators produced by microorganisms
and plants growing mostly under low iron conditions. Siderophores allow iron capture and …

Iron is an essential trace element that is limiting in most habitats including hosts for fungal
pathogens. Siderophores are iron-chelators synthesized by most fungal species for high …

Cefiderocol is a siderophore cephalosporin with potent antibacterial activity against a broad
range of Gram-negative pathogens, including multidrug-resistant strains. Siderophore …

The tale of abate in antibiotics continued defense mechanisms that chaperone the rise of
drug-defying superbugs—on the other hand, the astray in antibacterial drug discovery and …

The discovery of β-lactam (BL) antibiotics in the early 20th century represented a remarkable
advancement in human medicine, allowing for the widespread treatment of infectious …

The design and synthesis of narrow-spectrum antibiotics that target a specific bacterial
strain, species, or group of species is a promising strategy for treating bacterial infections …

Extensive antibiotic use combined with poor historical drug stewardship practices have
created a medical crisis in which once treatable bacterial infections are now increasingly …