Conjugation to Native and Nonnative Triscatecholate Siderophores Enhances Delivery and Antibacterial Activity of a β-Lactam to Gram-Negative Bacterial Pathogens
Developing new antibiotics and delivery strategies is of critical importance for treating
infections caused by Gram-negative bacterial pathogens. Hijacking bacterial iron uptake …
infections caused by Gram-negative bacterial pathogens. Hijacking bacterial iron uptake …
[HTML][HTML] Immunization of Chickens with the Enterobactin Conjugate Vaccine Reduced Campylobacter jejuni Colonization in the Intestine
Y Cui, F Guo, J Guo, X Cao, H Wang, B Yang, H Zhou… - Vaccines, 2020 - mdpi.com
Campylobacter jejuni is the leading bacterial cause of human enteritis in developed
countries. Chicken is the major animal reservoir of C. jejuni and a powerful infection model …
countries. Chicken is the major animal reservoir of C. jejuni and a powerful infection model …
[HTML][HTML] Biomimetic enterobactin analogue mediates iron-uptake and cargo transport into E. coli and P. aeruginosa
R Zscherp, J Coetzee, J Vornweg, J Grunenberg… - Chemical …, 2021 - pubs.rsc.org
The design, synthesis and biological evaluation of the artificial enterobactin analogue EntKL
and several fluorophore-conjugates thereof are described. EntKL provides an attachment …
and several fluorophore-conjugates thereof are described. EntKL provides an attachment …
[HTML][HTML] Characterization of siderophores from Escherichia coli strains through genome mining tools: an antiSMASH study
Although urinary tract infections (UTIs) affect many people, they are usually a disease
observed in women. UTIs happen when exogenous and endogenous bacteria enter the …
observed in women. UTIs happen when exogenous and endogenous bacteria enter the …
1, 2, 4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors
L Gavara, F Verdirosa, L Sevaille, A Legru… - Bioorganic & medicinal …, 2022 - Elsevier
Abstract Metallo-β-lactamases (MBLs) represent an increasingly serious threat to public
health because of their increased prevalence worldwide in relevant opportunistic Gram …
health because of their increased prevalence worldwide in relevant opportunistic Gram …
[HTML][HTML] Novel cyclic lipopeptide antibiotics: effects of acyl chain length and position
SK Jensen, TT Thomsen, A Oddo, H Franzyk… - International Journal of …, 2020 - mdpi.com
Multidrug-resistant bacteria are a global health problem. One of the last-resort antibiotics
against Gram-negative bacteria is the cyclic lipopeptide colistin, displaying a flexible linker …
against Gram-negative bacteria is the cyclic lipopeptide colistin, displaying a flexible linker …
Serratiochelin D, a new siderophore from Serratia marcescens
PM Eze, VE Simons, M Frank, L van Geelen… - Phytochemistry …, 2023 - Elsevier
A new siderophore, serratiochelin D (1), was isolated from a soil-derived, non-pigmented
strain of Serratia marcescens along with two previously reported siderophores …
strain of Serratia marcescens along with two previously reported siderophores …
[HTML][HTML] A Glimpse at Siderophores Production by Anabaena flos-aquae UTEX 1444
In this study, a strain of Anabaena flos-aquae UTEX 1444 was cultivated in six different
concentrations of iron (III). Cultures were extracted with organic solvents and analyzed using …
concentrations of iron (III). Cultures were extracted with organic solvents and analyzed using …
Metallotherapeutics development in the age of iron-clad bacteria
G Centola, F Xue, A Wilks - Metallomics, 2020 - academic.oup.com
Drug-resistant infections pose a significant risk to global health as pathogenic bacteria
become increasingly difficult to treat. The rapid selection of resistant strains through poor …
become increasingly difficult to treat. The rapid selection of resistant strains through poor …
[HTML][HTML] Conjugates of Iron-Transporting N-Hydroxylactams with Ciprofloxacin
Screening of a library of novel N-hydroxylactams amenable by the Castagnoli-Cushman
reaction identified four lead compounds that facilitated 55Fe transport into P. aeruginosa …
reaction identified four lead compounds that facilitated 55Fe transport into P. aeruginosa …