Leucyl-tRNA synthetase (LeuRS) is a clinically validated target for the development of
antimicrobials. This enzyme catalyzes the formation of charged tRNA Leu molecules, an …

A growing number of evidence shows that human-associated microbiota is an important
contributor in health and disease. However, much of the complexity of host-microbiota …

Bacteria secrete various iron-chelators (siderophores), which scavenge Fe3+ from the
environment, bind it with high affinity, and retrieve it inside the cell. After the Fe3+ uptake …

Siderophores are a class of small molecules renowned for their high iron binding capacity,
essential for all life forms requiring iron. This article provides a detailed review of the diverse …

Siderophores are well-recognized low-molecular-weight compounds produced by
numerous microorganisms to acquire iron from the surrounding environments. These …

Purpose: To evaluate the xenosiderophoric properties of siderophores produced by Serratia
marcescens towards Acinetobacter baumannii, Staphylococcus aureus and Mycobacterium …

Siderophores are metal chelating secondary metabolites secreted by almost all organisms.
Beside iron starvation, the ability to produce siderophores depends upon several other …

Bacterial thymidylate kinase (TMK) is a member of nucleoside monophosphate kinases and
recently becomes a protein of interest in the discovery of new antibacterial agents …

Critically ill patients often present with low serum iron levels or anemia. We evaluated the
impact of iron levels and iron homeostasis on the efficacy and safety of cefiderocol, an iron …

Antibiotic resistance is a major public health concern. The shrinking selection of effective
antibiotics and lack of new development is making the situation worse. Gram-negative …