[HTML][HTML] Synthesis of temporin L hydroxamate-based peptides and evaluation of their coordination properties with iron (III)

R Bellavita, L Leone, A Maione, L Falcigno… - Dalton …, 2023 - pubs.rsc.org
Ferric iron is an essential nutrient for bacterial growth. Pathogenic bacteria synthesize iron-
chelating entities known as siderophores to sequestrate ferric iron from host organisms in …

Current developments and prospects of the antibiotic delivery systems

K Kharga, S Jha, T Vishwakarma… - Critical Reviews in …, 2024 - Taylor & Francis
Antibiotics have remained the cornerstone for the treatment of bacterial infections ever since
their discovery in the twentieth century. The uproar over antibiotic resistance among bacteria …

Antibody–Antibiotic Conjugates: A Comprehensive Review on Their Therapeutic Potentials Against BacterialInfections

A Darbandi, M Abdi, S Dashtbin… - Journal of Clinical …, 2024 - Wiley Online Library
Introduction Antibodies are significant agents in the immune system and have proven to be
effective in treating bacterial infections. With the advancement of antibody engineering in …

Beyond antibiotics: Emerging antivirulence strategies to combat Pseudomonas aeruginosa in cystic fibrosis

U Mudgil, L Khullar, J Chadha, K Harjai - Microbial Pathogenesis, 2024 - Elsevier
Pseudomonas aeruginosa is an opportunistic pathogen that poses a significant threat to
individuals suffering from cystic fibrosis (CF). The pathogen is highly prevalent in CF …

Natural products from human microbiome: an emergent frontier in organic synthesis and drug discovery

G Mehta, S Sengupta, S Pabbaraja - Organic & Biomolecular …, 2024 - pubs.rsc.org
Often referred to as “second genome”, human microbiome is at the epicenter of a complex
inter-habitat biochemical network, such as the “gut-brain axis”, which have emerged as …

[HTML][HTML] Exploring Fe (III) coordination and membrane interaction of a siderophore-peptide conjugate: Enhancing synergistically the antimicrobial activity

R Bellavita, S Braccia, LE Imbò, P Grieco… - Journal of Inorganic …, 2024 - Elsevier
Many microbes produce siderophores, which are extremely potent weapons capable of
stealing iron ions from human tissues, fluids and cells and transferring them into bacteria …

Next-generation antibiotics, bacteriophage endolysins, and nanomaterials for combating pathogens

IG Shemyakin, VV Firstova, NK Fursova, IV Abaev… - Biochemistry …, 2020 - Springer
This review presents various strategies to fight causative agents of infectious diseases.
Species-specific programmable RNA-containing antibiotics open up new possibilities for …

[HTML][HTML] In vitro and in silico studies of enterobactin-inspired Ciprofloxacin and Fosfomycin first generation conjugates on the antibiotic resistant E. coli OQ866153

MT Khazaal, AHI Faraag, HH El-Hendawy - BMC microbiology, 2024 - Springer
Background The emergence of antimicrobial resistance in bacterial pathogens is a growing
concern worldwide due to its impact on the treatment of bacterial infections. The" Trojan …

Design, synthesis, structure elucidation, antimicrobial, molecular docking, and SAR studies of novel urea derivatives bearing tricyclic aromatic hydrocarbon rings

FM Sroor, AF El‐Sayed, M Abdelraof - Archiv der Pharmazie, 2024 - Wiley Online Library
The targeted compounds were prepared using both (9H‐fluoren‐9‐ylidene) hydrazine (1)
and 10H‐phenothiazine (2) as starting materials. The treatment of 1 or 2 with different …

[HTML][HTML] Novel Hydroxamic Acids Containing Aryl-Substituted 1, 2, 4-or 1, 3, 4-Oxadiazole Backbones and an Investigation of Their Antibiotic Potentiation Activity

AA Zhukovets, VV Chernyshov… - International Journal of …, 2023 - mdpi.com
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) is a zinc
amidase that catalyzes the second step of the biosynthesis of lipid A, which is an outer …