The functional roles of the circRNA/Wnt axis in cancer

C Xue, G Li, Q Zheng, X Gu, Z Bao, J Lu, L Li - Molecular Cancer, 2022 - Springer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer

Y Liu, X Ao, W Yu, Y Zhang, J Wang - Molecular Therapy-Nucleic Acids, 2022 - cell.com
Lung cancer (LC) is the leading cause of cancer-related deaths worldwide, with high
morbidity and mortality. Non-small cell lung cancer (NSCLC) is a major pathological type of …

Circular RNA Circ_0067934 attenuates ferroptosis of thyroid cancer cells by miR-545-3p/SLC7A11 signaling

HH Wang, JN Ma, XR Zhan - Frontiers in endocrinology, 2021 - frontiersin.org
Ferroptosis is an emerging programmed cell death distinguished from apoptosis and
autophagy and plays essential roles in tumorigenesis. Thyroid cancer is a prevalent …

Wnt/β-catenin-driven EMT regulation in human cancers

W Xue, L Yang, C Chen, M Ashrafizadeh, Y Tian… - Cellular and Molecular …, 2024 - Springer
Metastasis accounts for 90% of cancer-related deaths among the patients. The
transformation of epithelial cells into mesenchymal cells with molecular alterations can occur …

Critical roles of circular RNA in tumor metastasis via acting as a sponge of miRNA/isomiR

L Guo, L Jia, L Luo, X Xu, Y Xiang, Y Ren… - International Journal of …, 2022 - mdpi.com
Circular RNAs (circRNAs), a class of new endogenous non-coding RNAs (ncRNAs), are
closely related to the carcinogenic process and play a critical role in tumor metastasis …

Circ-HSP90A expedites cell growth, stemness, and immune evasion in non-small cell lung cancer by regulating STAT3 signaling and PD-1/PD-L1 checkpoint

J Lei, J Zhu, B Hui, C Jia, X Yan, T Jiang… - Cancer Immunology …, 2023 - Springer
Abstract Background Circular RNAs (circRNAs) are important participators in tumor
progression for their stable structure and high tissue-specific expression. The purpose of this …

[HTML][HTML] Circular RNAs: novel actors of Wnt signaling pathway in lung cancer progression

M Alimohammadi, Y Gholinezhad, V Mousavi… - EXCLI …, 2023 - ncbi.nlm.nih.gov
Abstract Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are
ubiquitously expressed in eukaryotes. CircRNA dysregulation has been shown to disrupt the …

[HTML][HTML] CircRNAs in lung cancer-role and clinical application

J Li, Q Zhang, D Jiang, J Shao, W Li, C Wang - Cancer Letters, 2022 - Elsevier
Lung cancer holds the highest mortality rate among malignancies worldwide. Nevertheless,
the potential molecular mechanisms of its tumorigenesis and evolution remain obscure …

Immunomodulatory functions of the circ_001678/miRNA-326/ZEB1 axis in non-small cell lung cancer via the regulation of PD-1/PD-L1 pathway

Q Tian, T Wu, X Zhang, K Xu, X Yin… - Human Molecular …, 2022 - academic.oup.com
High-throughput circular RNA (circRNA) sequencing identified circRNA_001678
(circ_001678) as an upregulated circRNA in non-small cell lung cancer (NSCLC) tissues …

Non-coding RNA-based therapeutics in cancer therapy: An emphasis on Wnt/β-catenin control

A Taheriazam, SD Bayanzadeh, MH Farahani… - European Journal of …, 2023 - Elsevier
Non-coding RNA transcripts are RNA molecules that have mainly regulatory functions and
they do not encode proteins. microRNAs (miRNAs), lncRNAs and circRNAs are major types …