The hypothesis that the anti-inflammatory activity of NSAIDs derives from COX inhibition is
well established. It also underpins the accepted mechanism of the gastrointestinal and renal …

Role of PGI2 in Vascular Diseases to the classical IP–cAMP signal pathway. 11 The role of
PPARδin VSMCs is somewhat controversial. It has been shown that the expression of …

Tight regulation of COX-2 expression is a key feature controlling eicosanoid production in
atherosclerosis and other inflammatory syndromes. Adhesive interactions between platelets …

Saikosaponin a (SSa), the major triterpenoid saponin derivatives from Radix bupleuri (RB),
has been reported to have anti-inflammatory effects. The aim of this study was to investigate …

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit production of prostaglandins by
acting on cyclooxygenase (COX) isoenzymes 1 and 2. Nonselective NSAIDs inhibit both …

Eicosanoids are biologically active lipids in both physiologic and pathophysiologic
situations. These mediators rapidly generate at sites of inflammation and act through specific …

The mechanisms involved in vascular homeostasis and disease are mostly dependent on
the interactions between blood, vascular smooth muscle, and endothelial cells. There is an …

Reactive oxygen species are oxygen derivates and play an active role in vascular biology.
These compounds are generated within the vascular wall, at the level of endothelial and …

The term aspirin resistance has been used increasingly in clinical studies. The aim of this
Review is to analyze the origin of this term, to discuss the biochemical, functional and …

Eicosanoids are potent biologically active arachidonic acid-derived lipid mediators that are
intimately involved in inflammation and cancer. Cyclooxygenase (COX), the key enzyme in …