Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity
KM Knights, AA Mangoni, JO Miners - Expert review of clinical …, 2010 - Taylor & Francis
The hypothesis that the anti-inflammatory activity of NSAIDs derives from COX inhibition is
well established. It also underpins the accepted mechanism of the gastrointestinal and renal …
well established. It also underpins the accepted mechanism of the gastrointestinal and renal …
Prostacyclin in Vascular Diseases–Recent Insights and Future Perspectives–
J Kawabe, F Ushikubi, N Hasebe - Circulation Journal, 2010 - jstage.jst.go.jp
Role of PGI2 in Vascular Diseases to the classical IP–cAMP signal pathway. 11 The role of
PPARδin VSMCs is somewhat controversial. It has been shown that the expression of …
PPARδin VSMCs is somewhat controversial. It has been shown that the expression of …
[HTML][HTML] Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling
DA Dixon, ND Tolley, K Bemis-Standoli… - The Journal of …, 2006 - Am Soc Clin Investig
Tight regulation of COX-2 expression is a key feature controlling eicosanoid production in
atherosclerosis and other inflammatory syndromes. Adhesive interactions between platelets …
atherosclerosis and other inflammatory syndromes. Adhesive interactions between platelets …
Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in Human umbilical vein endothelial cells via preventing TLR4 translocation into lipid …
Y Fu, X Hu, Y Cao, Z Zhang, N Zhang - Free Radical Biology and Medicine, 2015 - Elsevier
Saikosaponin a (SSa), the major triterpenoid saponin derivatives from Radix bupleuri (RB),
has been reported to have anti-inflammatory effects. The aim of this study was to investigate …
has been reported to have anti-inflammatory effects. The aim of this study was to investigate …
Use of nonsteroidal anti-inflammatory drugs in patients with cardiovascular disease: a cautionary tale
M Amer, VR Bead, J Bathon, RS Blumenthal… - Cardiology in …, 2010 - journals.lww.com
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit production of prostaglandins by
acting on cyclooxygenase (COX) isoenzymes 1 and 2. Nonselective NSAIDs inhibit both …
acting on cyclooxygenase (COX) isoenzymes 1 and 2. Nonselective NSAIDs inhibit both …
Eicosanoids and their drugs in cardiovascular diseases: focus on atherosclerosis and stroke
Eicosanoids are biologically active lipids in both physiologic and pathophysiologic
situations. These mediators rapidly generate at sites of inflammation and act through specific …
situations. These mediators rapidly generate at sites of inflammation and act through specific …
Prostanoid receptors in the human vascular wall
X Norel - The Scientific World Journal, 2007 - Wiley Online Library
The mechanisms involved in vascular homeostasis and disease are mostly dependent on
the interactions between blood, vascular smooth muscle, and endothelial cells. There is an …
the interactions between blood, vascular smooth muscle, and endothelial cells. There is an …
Oxidative stress and vascular damage in hypertension: role of angiotensin II
A Virdis, E Duranti, S Taddei - International journal of …, 2011 - Wiley Online Library
Reactive oxygen species are oxygen derivates and play an active role in vascular biology.
These compounds are generated within the vascular wall, at the level of endothelial and …
These compounds are generated within the vascular wall, at the level of endothelial and …
Drug insight: aspirin resistance—fact or fashion?
The term aspirin resistance has been used increasingly in clinical studies. The aim of this
Review is to analyze the origin of this term, to discuss the biochemical, functional and …
Review is to analyze the origin of this term, to discuss the biochemical, functional and …
Pharmacological intervention of cyclooxygenase-2 and 5-lipoxygenase pathways. Impact on inflammation and cancer
J Claria, M Romano - Current pharmaceutical design, 2005 - ingentaconnect.com
Eicosanoids are potent biologically active arachidonic acid-derived lipid mediators that are
intimately involved in inflammation and cancer. Cyclooxygenase (COX), the key enzyme in …
intimately involved in inflammation and cancer. Cyclooxygenase (COX), the key enzyme in …