BACKGROUND: Recently, a growing body of evidence on the possible role of residual
platelet reactivity (RPR) in affecting clinical events has accumulated. The aim of this study …

Treatment failures occur with any drug and aspirin is no exception. Evidence is growing to
indicate that there are subpopulations that do not respond to antithrombotic action of aspirin …

Atherothrombosis, characterized by atherosclerotic plaque rupture and subsequent
occlusive or subocclusive thrombus formation is the primary cause of acute ischemic …

Chronic hyperglycemia favours the formation of advanced glycation end products (AGEs)
which are responsible of many diabetic vascular complications. Keeping in view the …

В течение последнего десятилетия круг заболеваний, развитие которых связано с
хроническим иммунным воспа лением, неуклонно расширяется [1]. Особое внимание …

Inflammation plays a central role in the development of atherosclerotic disease, from the
early phases of lesion formation to plaque disruption, the main underlying cause of acute …

Introduction: The study of pharmacogenomics presents the possibility of individualised
optimisation of drug therapy tailored to each patients' unique physiological traits. Both …

Aspirin, an irreversible inhibitor of platelet prostaglandin synthase activity, is the cornerstone
of therapy for acute coronary syndromes. In recent years, laboratory and clinical data have …

Comment significant decrease in the frequency of upper gastrointestinal ulcer complications
in patients not taking low-dose aspirin (64 [0· 92%] vs 14 [0· 20%]). Thus, the number …

Sulforaphane (SFN), mainly derived from cruciferous vegetables, has received much
attention for its cancer chemopreventive property. Though there have been a few …