There is concern that cyclooxygenase (COX)-2 inhibitors may promote atherothrombosis by
inhibiting vascular formation of prostacyclin (PGI2) and an increased thrombotic risk of COX …

Inflammation plays an essential role in atherosclerosis and post‐angioplasty restenosis and
the synthesis and release of inflammatory cytokines from vascular smooth muscle cells is an …

Angiotensin II induces endothelial dysfunction by reducing NO availability and increasing
reactive oxygen species. We assessed whether cyclooxygenase (COX)-1 or COX-2 …

Aims Endothelial dysfunction, platelet hyperactivity, and inflammation play a crucial role in
atherogenesis. A growing body of evidence suggests that inhibition of the thromboxane A2 …

Although cyclooxygenase (COX)-2 inhibitors (coxibs) are effective in controlling
inflammation, pain, and tumorigenesis, their use is limited by the recent revelation of …

Lipids and endothelium are pivotal players on the scene of atherosclerosis and their
interaction is crucial for the establishment of the pathological processes. The endothelium is …

Despite initial promising reports that anti-inflammatory properties of cycloxygenase-2 (COX-
2) inhibitors may confer anti-atherosclerosis effects and stabilize the atherosclerotic plaque …

Cyclooxygenase‐2 selective inhibitors (COXIBs) were developed with the prime object of
minimizing gastrointestinal adverse effects, which are seen with the use of traditional …

Cyclooxygenase (COX) enzymes catalyse the biotransformation of arachidonic acid to
prostaglandins which subserve important functions in cardiovascular homeostasis …

Aspirin is an effective antiplatelet agent with proven benefit in the prevention of
atherothrombotic complications of cardiovascular disease. The antithrombotic effects of …