CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental …
AP Davis, TC Wiegers, J Wiegers, B Wyatt… - Toxicological …, 2023 - academic.oup.com
The molecular mechanisms connecting environmental exposures to adverse endpoints are
often unknown, reflecting knowledge gaps. At the Comparative Toxicogenomics Database …
often unknown, reflecting knowledge gaps. At the Comparative Toxicogenomics Database …
Environmental Factors as the Main Hormonal Disruptors of Male Fertility
N Wdowiak, K Wójtowicz, A Wdowiak-Filip… - Journal of Clinical …, 2024 - mdpi.com
Introduction and objective: Many scientific reports confirm a systematic decline in male
semen parameters over the last decades. This phenomenon has been observed in all parts …
semen parameters over the last decades. This phenomenon has been observed in all parts …
Deteriorating Semen Quality: The Role of the Environment
HE Virtanen, W Rodprasert… - Seminars in Reproductive …, 2023 - thieme-connect.com
Since the end of the last century, several reports have suggested that semen quality is
declining, especially in Western countries. Furthermore, cross-sectional studies using similar …
declining, especially in Western countries. Furthermore, cross-sectional studies using similar …
FTO-Nrf2 axis regulates bisphenol F-induced leydig cell toxicity in an m6A-YTHDF2-dependent manner
S Zhou, J Li, H Chen, Y Zeng, W Yuan, Y Shi… - Environmental …, 2023 - Elsevier
Studies have shown that Bisphenol F (BPF) as an emerging bisphenol pollutant also has
caused many hazards to the reproductive systems of humans and animals. However, its …
caused many hazards to the reproductive systems of humans and animals. However, its …
Smoking induces a decline in semen quality and the activation of stress response pathways in sperm
MC Henriques, J Santiago, A Patrício, MT Herdeiro… - Antioxidants, 2023 - mdpi.com
Male infertility is a prevalent concern affecting couples worldwide. While genetic factors,
hormonal imbalances, and reproductive system defects play significant roles, emerging …
hormonal imbalances, and reproductive system defects play significant roles, emerging …
BNC1 deficiency induces mitochondrial dysfunction-triggered spermatogonia apoptosis through the CREB/SIRT1/FOXO3 pathway: the therapeutic potential of …
F Ni, F Wang, J Li, Y Liu, X Sun, J Chen… - Biology of …, 2024 - academic.oup.com
Male infertility is a global health problem that disturbs numerous couples worldwide.
Basonuclin 1 (BNC1) is a transcription factor mainly expressed in proliferative keratinocytes …
Basonuclin 1 (BNC1) is a transcription factor mainly expressed in proliferative keratinocytes …
Semen damage contributed over 50% to air-pollutant-induced infertility: A prospective cohort study of 3940 men in China
Y Guo, Q Chen, Y Zhan, W Zhou, H Zhang… - Science of The Total …, 2023 - Elsevier
Objective To investigate the contribution of ambient air pollutants-induced semen damage to
infertility risk, after identifying dose-response relationship between pollutants and semen …
infertility risk, after identifying dose-response relationship between pollutants and semen …
The palliative and antioxidant effects of hesperidin against lead-acetate-induced testicular injury in male wistar rats
R Abu-Khudir, HH Almutairi, SS Abd El-Rahman… - Biomedicines, 2023 - mdpi.com
Lead (Pb)-induced reprotoxicity is a detrimental consequence of Pb exposure, which results
in abnormal spermatogenesis, testicular degeneration, and pathogenic sperm changes. The …
in abnormal spermatogenesis, testicular degeneration, and pathogenic sperm changes. The …
Prepubertal oral exposure to relevant doses of acrylamide impairs the testicular antioxidant system in adulthood, increasing protein carbonylation and lipid …
LD Dos Santos, TL de Souza, GI da Silva… - Environmental …, 2023 - Elsevier
The increased prevalence of human infertility due to male reproductive disorders has been
linked to extensive exposure to chemical endocrine disruptors. Acrylamide (AA) is a …
linked to extensive exposure to chemical endocrine disruptors. Acrylamide (AA) is a …
Novel findings from arsenic‑lead combined exposure in mouse testicular TM4 Sertoli cells based on transcriptomics
X Zheng, C Guo, Z Lv, J Li, H Jiang, S Li, L Yu… - Science of The Total …, 2024 - Elsevier
Abstract Arsenic (As) and lead (Pb) exist widespread in daily life, and they are common
harmful substances in the environment. As and Pb pollute the environment more often in …
harmful substances in the environment. As and Pb pollute the environment more often in …