Craniofacial development involves several complex tissue movements including several
fusion processes to form the frontonasal and maxillary structures, including the upper lip and …

BMP signaling is one of the key pathways regulating craniofacial development. It is involved
in the early patterning of the head, the development of cranial neural crest cells, and facial …

Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …

The bone morphogenetic protein (BMP) signaling pathway is highly conserved across many
species, and its importance for the patterning of the skeletal system has been demonstrated …

The mammalian lip and primary palate form when coordinated growth and morphogenesis
bring the nasal and maxillary processes into contact, and the epithelia co-mingle, remodel …

Nonsyndromic orofacial clefts are common birth defects with multifactorial etiology. The most
common type is cleft lip, which occurs with or without cleft palate (nsCLP and nsCLO …

Cranial neural crest cells (NCCs) are the origin of the anterior part of the face and the head.
Cranial NCCs are multipotent cells giving rise to bones, cartilage, adipose-tissues in the …

Cleft lip is one of the most common human birth defects. However, there remain a limited
number of mouse models of cleft lip that can be leveraged to characterize the genes and …

Aim To date, controversies still exist regarding the exact cellular origin and regulatory
mechanisms of periodontium development, which hinders efforts to achieve ideal …

The mandibular and hyoid arches collectively make up the facial skeleton, also known as
the viscerocranium. Although all three germ layers come together to assemble the …