Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases
G Zagnoli-Vieira, KW Caldecott - DNA repair, 2020 - Elsevier
DNA topoisomerases alleviate the torsional stress that is generated by processes that are
central to genome metabolism such as transcription and DNA replication. To do so, these …
central to genome metabolism such as transcription and DNA replication. To do so, these …
[HTML][HTML] Protein nucleotidylylation in+ ssRNA viruses
AR Eruera, AM McSweeney, GM McKenzie-Goldsmith… - Viruses, 2021 - mdpi.com
Nucleotidylylation is a post-transcriptional modification important for replication in the
picornavirus supergroup of RNA viruses, including members of the Caliciviridae …
picornavirus supergroup of RNA viruses, including members of the Caliciviridae …
Multiple Viral Protein Genome-Linked Proteins Compensate for Viral Translation in a Positive-Sense Single-Stranded RNA Virus Infection
R Warsaba, N Stoynov, KM Moon, S Flibotte… - Journal of …, 2022 - Am Soc Microbiol
Viral protein genome-linked (VPg) protein plays an essential role in protein-primed
replication of plus-stranded RNA viruses. VPg is covalently linked to the 5′ end of the viral …
replication of plus-stranded RNA viruses. VPg is covalently linked to the 5′ end of the viral …
[HTML][HTML] A Proximity biotinylation assay with a host protein bait reveals multiple factors modulating enterovirus replication
As ultimate parasites, viruses depend on host factors for every step of their life cycle. On the
other hand, cells evolved multiple mechanisms of detecting and interfering with viral …
other hand, cells evolved multiple mechanisms of detecting and interfering with viral …
Post-translational regulation of Tyrosyl-DNA phosphodiesterase (TDP1 and TDP2) for the repair of the trapped topoisomerase-DNA covalent complex
DNA topoisomerases are essential enzymes that regulate DNA topology, the transmission of
genetic materials, and gene expressions both in the nucleus and mitochondria. Trapped …
genetic materials, and gene expressions both in the nucleus and mitochondria. Trapped …
TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligases
A Shulkina, K Hacker, JF Ehrmann, V Budroni… - bioRxiv, 2024 - biorxiv.org
Tripartite motif 52 (TRIM52) exhibits strong positive selection in humans, yet is lost in many
other mammals. In contrast to what one would expect for such a non-conserved factor …
other mammals. In contrast to what one would expect for such a non-conserved factor …
Multiple viral protein genome-linked proteins compensate viral translation in a+ ssRNA virus infection
Viral protein genome-linked (VPg) protein plays an essential role in protein-primed
replication of plus stranded RNA viruses. VPg is covalently linked to the 5'end of the viral …
replication of plus stranded RNA viruses. VPg is covalently linked to the 5'end of the viral …
Multiple viral protein genome linked proteins in dicistrovirus infection
R Warsaba - 2022 - open.library.ubc.ca
Viral protein genome-linked (VPg) protein plays an essential role in protein-primed
replication of positive-sense single-stranded RNA viruses. VPg is covalently linked to the …
replication of positive-sense single-stranded RNA viruses. VPg is covalently linked to the …
Causes of DNA Damage and Genomic Instability: A Review
Genomic instability defines all genetic alterations resulting from excessive or high frequency
of mutation; base pairs sequence alterations known as microsatellite instability (MSI) and …
of mutation; base pairs sequence alterations known as microsatellite instability (MSI) and …