Multiple myeloma is an incurable cancer characterized by the uncontrolled growth of
malignant plasma cells nurtured within a permissive bone marrow microenvironment. While …

The ubiquitin–proteasome system (UPS) is involved in multiple cellular functions including
the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen …

Proteasome is a multi-subunit protein degradation machine, which plays a key role in the
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …

Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …

Proteasomes are broadly expressed key components of the ubiquitin-dependent protein
degradation pathway containing catalytically active subunits (β1, β2, and β5). LMP7 (β5i) is …

Abstract Large multifunctional peptidase 7 (LMP7/β5i/PSMB8) is a proteolytic subunit of the
immunoproteasome, which is predominantly expressed in normal and malignant …

Aims/hypothesis The inflammatory milieu characteristic of insulitis affects translation fidelity
and generates defective ribosomal products (DRiPs) that participate in autoimmune beta cell …

Multiple myeloma (MM), a cancer of plasma cells, is the second most common
hematological malignancy which is characterized by aberrant plasma cells infiltration in the …

The immunoproteasome is a specialized form of proteasome equipped with modified
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …

Background The worldwide pandemic caused by the SARS-CoV-2 virus is characterized by
significant and unpredictable heterogeneity in symptoms that remains poorly understood …