In the present study we have characterized the evolution of changes in systemic
haemodynamics (thermodilution in conscious animals) and sodium balance (metabolic …

Background: Mechanisms underlying abnormalities of circulation and renal function in
cirrhosis are not completely understood. Our previous study revealed that primary afferent …

Vitamin E prevents renal dysfunction induced by experimental chronic bile duct ligation.
Background The mechanisms by which prolonged cholestasis alters renal hemodynamics …

The characteristic cardiovascular changes in liver cirrhosis are vasodilatation and increased
cardiac output. Augmented activity of the vasorelaxant factor, nitric oxide (NO), stimulated by …

Bile duct ligation (BDL) in rats induces portal fibrosis. This process has been linked to
changes in the oxidative state of the hepatic cells and in the production of nitric oxide. Our …

Background/aims. This experimental study was designed to evaluate histological changes of
the kidney and renal tissue levels of malondialdehyde (MDA), reduced glutathione (GSH) …

Nebivolol is a new selective beta 1‐adrenoceptor antagonist with nitric oxide (NO)–
releasing properties. In the present study we have analyzed whether nebivolol affects the …

Abstract Background and Aims: Increased levels of nitric oxide (NO) are hypothesized to
contribute to renal dysfunction in patients with decompensated cirrhosis. In this study, we …

This study was designed to test the hypothesis that glomerular de novo expression of
inducible nitric oxide synthase (iNOS) contributes to renal hemodynamic abnormalities in …

The aims of the present work were to study the effects of chronic NO inhibition on liver
cirrhosis and to analyze its relationship with liver and kidney damage markers. Two …