Fluorocarbons and fluorinated amphiphiles in drug delivery and biomedical research

MP Krafft - Advanced drug delivery reviews, 2001 - Elsevier
The specific properties of fluorocarbons, exceptional chemical and biological inertness, high
gas-dissolving capacity, low surface tension, excellent spreading characteristics and high …

Highly fluorinated amphiphiles and colloidal systems, and their applications in the biomedical field. A contribution

MP Krafft, JG Riess - Biochimie, 1998 - Elsevier
Fluorocarbons and fluorocarbon moieties are uniquely characterized by very strong
intramolecular bonds and very weak intermolecular interactions. This results in a …

Blood substitutes Artificial oxygen carriers: perfluorocarbon emulsions

DR Spahn - Critical Care, 1999 - Springer
Perfluorocarbon emulsions are being clinically evaluated as artificial oxygen carriers to
reduce allogeneic blood transfusions or to improve tissue oxygenation. Perfluorocarbon …

Fluorinated materials for in vivo oxygen transport (blood substitutes), diagnosis and drug delivery

JG Riess, MP Krafft - Biomaterials, 1998 - Elsevier
Fluorocarbons are characterized by exceptional chemical and biological inertness, extreme
hydrophobicity, lipophobicity, high gas-dissolving capacities, low surface tensions, high …

Bio‐inspired nanomedicine strategies for artificial blood components

A Sen Gupta - Wiley Interdisciplinary Reviews: Nanomedicine …, 2017 - Wiley Online Library
Blood is a fluid connective tissue where living cells are suspended in noncellular liquid
matrix. The cellular components of blood render gas exchange (RBCs), immune …

Perflubron emulsion delays blood transfusions in orthopedic surgery

DR Spahn, R van Brempt, G Theilmeier… - The Journal of the …, 1999 - pubs.asahq.org
Background Fluorocarbon emulsions have been proposed as temporary artificial oxygen
carriers. The aim of the present study is to compare the effectiveness of perflubron emulsion …

Artificial O2 carriers: status in 2005

DR Spahn, R Kocian - Current pharmaceutical design, 2005 - ingentaconnect.com
Donor blood is a limited resource and its transfusion is associated with significant adverse
effects. Therefore, alternatives have been searched, the ultimate being artificial oxygen (O2) …

Assessment of nanoparticle-mediated tumor oxygen modulation by photoacoustic imaging

M Sivasubramanian, LW Lo - Biosensors, 2022 - mdpi.com
Photoacoustic imaging (PAI) is an invaluable tool in biomedical imaging, as it provides
anatomical and functional information in real time. Its ability to image at clinically relevant …

Delivery of thymoquinone to cancer cells with as1411-conjugated nanodroplets

EM Murphy, CS Centner, PJ Bates, MT Malik… - PLoS …, 2020 - journals.plos.org
Systemic delivery of conventional chemotherapies can cause negative systemic toxicity,
including reduced immunity and damage to organs such as the heart and kidneys—limiting …

Current status of artificial oxygen carriers

DR Spahn - Advanced drug delivery reviews, 2000 - Elsevier
Artificial oxygen carriers may be grouped into modified hemoglobin solutions and
fluorocarbon emulsions. In animal experiments, both have been shown to be efficacious in …