Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the
spine are biomechanically interdependent, typically occur in tandem, and have considerable …

Although aging has traditionally been viewed as the most important risk factor for
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …

In the context of accelerated aging of the population worldwide, frailty has emerged as one
of the main risk factors that can lead to loss of self-sufficiency in older people. This syndrome …

Aims Rheumatoid arthritis (RA) is a common chronic immune disease. Berberine, as its main
active ingredient, was also contained in a variety of medicinal plants such as Berberaceae …

Erectile dysfunction (ED) is an adverse side effect of pelvic surgery with no effective
treatment. In this study, it is explored whether melatonin could improve the therapeutic …

Osteoarthritis (OA) is a frequent musculoskeletal disorder affecting millions of people
worldwide. Despite advances in understanding the pathogenesis of OA, prognostic …

Bone homeostasis, depending on the balance between bone formation and bone
resorption, is responsible for maintaining the proper structure and function of the skeletal …

Septic arthritis induced by Staphylococcus aureus (S. aureus) causes irreversible cartilage
degradation and subsequent permanent joint dysfunction. Recently, cartilage degradation in …

Knee osteoarthritis (KOA) is a chronic, disabling knee joint lesion in which degeneration and
defects in articular cartilage are the most important features. Casticin (CAS) is a flavonoid …

Focal lesions of articular cartilage give rise to pain and reduced joint function and may, if left
untreated, lead to osteoarthritis. Implantation of in vitro generated, scaffold-free autologous …