ABSTRACT Introduction: Proton pump inhibitors (PPIs) are among the most commonly
prescribed drugs worldwide. However, concerns are growing about the serious adverse …

Aims The evidence of a protective effect of protonpump inhibitor (PPI) in oral anticoagulant
(OAC)treated patients against gastrointestinal bleeding (GIB) is still lacking. We conducted …

Aim Previous studies on the association between proton pump inhibitor (PPI) intake and the
increased risk of dementia has shown discrepancies in their conclusions. We aimed to …

METHODS: A population-based cohort study using the Korean National Health Insurance
Services Database. The participants with first prescription of PPIs and H 2 RA with normal …

Small intestinal bacterial overgrowth (SIBO) is a clinical disorder that results from the
colonization of the small bowel by increased numbers and/or abnormal types of …

Patients with severe infections and a pre-existing indication for antithrombotic therapy, ie
antiplatelet agents, anticoagulant drugs, or their combinations, require integrated clinical …

Less than 2 centuries have elapsed since the identification of hydrochloric acid in the
stomach. The clarification of the molecular mechanisms allowed the effective therapeutic …

Importance Proton pump inhibitor (PPI) use has been linked to increased risk of fracture in
adults. Despite a trend in prescription of PPIs in children, there is scarce evidence regarding …

Abstract Introduction Approximately 20–33% of all cancer patients are treated with acid-
reducing agents (ARAs), most commonly proton pump inhibitors (PPIs), to reduce …

Purpose of review Peptic ulcer disease (PUD) is a recognized complication of non-steroidal
anti-inflammatory drugs (NSAIDs). Stress ulcers are a concern for intensive care unit (ICU) …