Background Lung fluid balance in the healthy lung is dependent upon finely regulated
vectorial transport of ions across the alveolar epithelium. Classically, the cellular locus of the …

The COVID-19 pandemic has been a global health crisis of unprecedented magnitude. In
the battle against the SARS-CoV-2 coronavirus, dexamethasone, a widely used …

Abstract Purpose of Review Organogenesis is the process during development by which
cells self-assemble into complex, multi-scale tissues. While significant focus and research …

Stimulation of active fluid transport with β-adrenergic receptor (βAR) agonists can accelerate
the resolution of alveolar edema. However, chronic βAR-agonist administration may cause …

Background The intratracheal instillation of Pseudomonas aeruginosa entrapped in agar
beads in the mouse lung leads to chronic lung infection in susceptible mouse strains. As the …

Active transepithelial transport of sodium from the airspaces to the lung interstitium is a
primary mechanism driving alveolar fluid clearance. This mechanism depends on sodium …

We tested the hypothesis that labor-induced epinephrine release would stimulate alveolar
fluid clearance in preterm fetuses. Preterm fetuses were obtained by cesarean section from …

The present study was performed to investigate simultaneously total lung water, T 1 and T 2
relaxation times, and hyaluronan (HA) in preterm and term rabbits. Attempts were also made …

Cl− transport is essential for lung development. Because gamma-aminobutyric acid (GABA)
receptors allow the flow of negatively-charged Cl− ions across the cell membrane, we …

Abstract Background Small interfering RNA (siRNA) against αENaC (α-subunit of the
epithelial Na channel) and CFTR (cystic fibrosis transmembrane conductance regulator) …