Using a philosophical approach or deductive reasoning, we challenge the dominant clinico-
radiological worldview that defines multiple sclerosis (MS) as a focal inflammatory disease …

Dengue is one of the most typical viral infection categorized in the Neglected Tropical
Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and …

Equine piroplasmosis (EP), caused by the hemoparasites Theileria equi, Theileria haneyi,
and Babesia caballi, is an important tick-borne disease of equines that is prevalent in most …

Human dihydroorotate dehydrogenase (hDHODH) is a flavin-dependent enzyme catalyzing
the fourth step of pyrimidine de novo biosynthesis. Since aberrant pyrimidine metabolism is …

Introduction Pyrimidine nucleotides are essential for the parasite's growth and replication.
Parasites have only a de novo pathway for the biosynthesis of pyrimidine nucleotides …

Invasive fungal infections (IFIs) pose a serious clinical problem, but the antifungal arsenal is
limited and has many disadvantages, such as drug resistance and toxicity. Hence, there is …

The coronavirus disease-2019 (COVID-19) pandemic continues to challenge health care
systems around the world. Scientists and pharmaceutical companies have promptly …

Human dihydroorotate dehydrogenase (h DHODH) is an attractive tumor target essential to
de novo pyrimidine biosynthesis. Novel potent h DHODH inhibitors with low toxicity are …

Leflunomide (LF) represents the prototype member of dihydroorotate dehydrogenase
(DHODH) enzyme inhibitors. DHODH is a mitochondrial inner membrane enzyme …

Profiling approaches have been increasingly employed for the characterization of disease‐
relevant phenotypes or compound perturbation as they provide a broad, unbiased view on …