The success of gene therapy is largely dependent on the development of the gene delivery
vector. Recently, gene transfection into target cells using naked DNA, which is a simple and …

Offering the latest information in magnetic nanoparticle (MNP) research, Magnetic
Nanoparticles: From Fabrication to Clinical Applications provides a comprehensive review …

The availability of genetically altered cells is an essential prerequisite for many scientific and
therapeutic applications including functional genomics, drug development, and gene …

We previously reported that gene delivery efficiency of 25-kDa, branched polyethylenimine
(PEI) increased upon acetylation of up to 43% of the primary amines with acetic anhydride …

Nucleic acid drugs have great potential to treat many devastating aliments, but their
application has been hindered by the lack of efficacious and nontoxic delivery vehicles …

Abstract miR-122, a liver-specific tumor suppressor microRNA, is frequently down-regulated
in hepatocellular carcinoma (HCC). LNP-DP1, a cationic lipid nanoparticle formulation, was …

Introduction: Current gene therapy involves replacement of defective gene by delivery of
healthy genetic material to precede normal function. Virus-mediated gene delivery is the …

To illuminate the function of the thousands of genes that make up the complexity of the
nervous system, it is critical to be able to introduce and express DNA in neurons. Over the …

Immunostimulatory oligodeoxynucleotides (ODN) containing cytosine-guanine (CpG) motifs
are powerful stimulators of innate as well as adaptive immune responses, exerting their …

Gene therapy is a promising strategy for the treatment of several inherited and acquired
human diseases. Several vector platforms exist for the delivery of therapeutic nucleic acids …