Biological membranes are complex and dynamic assemblies of lipids and proteins.
Poikilothermic organisms including bacteria, fungi, reptiles, and fish do not control their body …

Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …

The nuclear envelope (NE) is a spherical double membrane with elastic properties. How NE
shape and elasticity are regulated by lipid chemistry is unknown. Here we discover lipid acyl …

Cuticular waxes and cutin form the cuticle, a hydrophobic layer covering the aerial surfaces
of land plants and acting as a protective barrier against environmental stresses. Very-long …

Although the transcriptome, proteome, and interactome of several eukaryotic model
organisms have been described in detail, lipidomes remain relatively uncharacterized …

During the last decades, lipids have gained much attention due to their involvement in
health and disease. Lipids are required for the formation of membranes and contribute to …

Due to its genetic tractability and increasing wealth of accessible data, the yeast
Saccharomyces cerevisiae is a model system of choice for the study of the genetics …

Cells maintain membrane fluidity by regulating lipid saturation, but the molecular
mechanisms of this homeoviscous adaptation remain poorly understood. We have …

Despite the essential roles of sphingolipids both as structural components of membranes
and critical signalling molecules, we have a limited understanding of how cells sense and …

Mass spectrometry-based shotgun lipidomics has enabled the quantitative and
comprehensive assessment of cellular lipid compositions. The yeast Saccharomyces …