Introduction The treatment landscape of hepatocellular carcinoma (HCC) has significantly
changed over the last 5 years with multiple options in the frontline, second line, and beyond …

Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results
from chronic liver injury as well as persistent activation of inflammatory response and of …

Abstract Background Circular RNAs (circRNAs) can be encapsulated into exosomes to
participate in intercellular communication, affecting the malignant progression of a variety of …

Background T cells form the major component of anti-tumor immunity. A deeper
understanding of T cell exhaustion (TEX) heterogeneity within the tumor microenvironment …

Immune checkpoint blockade (ICB) therapies have brought unprecedented advances in
cancer treatment, but responses are limited to a fraction of patients. Therefore, sustained …

The combination of atezolizumab plus bevacizumab (atezo/bev) has dramatically changed
the treatment landscape of advanced HCC (aHCC), achieving durable responses in some …

Simple Summary Hepatocellular carcinoma (HCC) represents one of the main indications
for liver transplantation. Over recent years, immune checkpoint inhibitor (ICI) therapy has …

Tumor-infiltrating lymphocytes (TIL) often include a substantial subset of CD8+ tissue-
resident memory T (TRM) cells enriched in tumor-specific T cells. These TRM cells play a …

Background & Aims Pyruvate dehydrogenase (PDC)-E2 specific CD8+ T cells play a leading
role in biliary destruction in PBC. However, there are limited data on the characterization of …

Regulatory T-Cells (Tregs) are important in the progression of hepatocellular cancer (HCC).
The goal of this work was to look into Tregs-related genes and develop a Tregs-related …