Neurodegenerative disorders affect almost 30 million individuals leading to disability and
death. These disorders are characterized by pathological changes in disease-specific areas …

Pericytes are branched cells embedded within the basement membrane of capillaries and
post-capillary venules. They provide an incomplete investment to endothelial cells, thus …

Background The genetic architecture of complex traits in farmed animal populations is of
interest from a scientific and practical perspective. The use of genetic markers to predict the …

Early‐onset Alzheimer's disease (EOAD) is generally known as a dominant disease due to
highly penetrant pathogenic mutations in the amyloid precursor protein, presenilin 1 and 2 …

A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents
of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein …

Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibroblasts) are known
to communicate with one another. Their interactions not only serve to support fully functional …

Notch signalling is critically involved in vascular morphogenesis and function. Four Notch
isoforms (Notch1–4) regulating diverse cellular processes have been identified. Of these …

Rationale: The heterotypic interactions of endothelial cells and mural cells (smooth muscle
cells or pericytes) are crucial for assembly, maturation, and subsequent function of blood …

Background—Notch signaling in vascular smooth muscle precursors is required for smooth
muscle differentiation. Jagged1 expression on endothelium activates Notch in vascular …

Within the pulmonary arterial tree, the NOTCH3 pathway is crucial in controlling vascular
smooth muscle cell proliferation and maintaining smooth muscle cells in an undifferentiated …