Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …

Decades of research have produced no effective method to prevent, delay the onset, or slow
the progression of Alzheimer's disease (AD). In contrast to these failures …

Alzheimer's disease (AD) remains a major cause of morbidity and mortality worldwide, and
despite extensive research, only a few drugs are available for management of the disease …

The presence of insoluble aggregates of amyloid β (Aβ) in the form of neuritic plaques (NPs)
is one of the main features that define Alzheimer's disease. Studies have suggested that the …

Background Postoperative delirium (POD) is a frequent complication after surgery and its
occurrence is associated with poor outcomes. The neuropathology of this complication is …

Introduction Alzheimer's disease (AD) is the most prevalent form of dementia with symptoms
of deteriorating cognitive functions and memory loss, partially as a result of a decrease in …

Gradual decline in cholinergic transmission and cognitive function occurs during normal
aging, whereas pathological loss of cholinergic function is a hallmark of different types of …

Background Subjective cognitive decline (SCD) is a risk factor for future cognitive
impairment and dementia. It is uncertain whether the neurodegeneration of the cholinergic …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is increasingly
viewed as a complex multi-dimensional disease without effective treatments. Recent …