[HTML][HTML] Neuroinflammation in post-traumatic epilepsy: pathophysiology and tractable therapeutic targets

R Sharma, WL Leung, A Zamani, TJ O'brien… - Brain sciences, 2019 - mdpi.com
Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to
increased morbidity and mortality for survivors. As post-traumatic epilepsy (PTE) is drug …

Neurotoxicity of fine and ultrafine particulate matter: A comprehensive review using a toxicity pathway-oriented adverse outcome pathway framework

SJ Qin, QG Zeng, HX Zeng, SP Li, J Andersson… - Science of The Total …, 2024 - Elsevier
Abstract Fine particulate matter (PM 2.5) can cause brain damage and diseases. Of note,
ultrafine particles (UFPs) with an aerodynamic diameter less than or equal to 100 nm are a …

Hesperetin confers neuroprotection by regulating Nrf2/TLR4/NF-κB signaling in an Aβ mouse model

M Ikram, T Muhammad, SU Rehman, A Khan… - Molecular …, 2019 - Springer
Hesperetin is a bioactive flavonoid in the body, produced from hesperidin. No
comprehensive studies have shown its protective effects in neurodegenerative disorders …

[HTML][HTML] Iron exposure and the cellular mechanisms linked to neuron degeneration in adult mice

LB Li, R Chai, S Zhang, SF Xu, YH Zhang, HL Li… - Cells, 2019 - mdpi.com
Although the causal relationship between Alzheimer's disease (AD) and iron overload
remains unclear, iron dyshomeostasis or improper transport mechanisms are speculated to …

Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of …

T Saito, S Hisahara, N Iwahara, MC Emoto… - Free Radical Biology …, 2019 - Elsevier
Alzheimer's disease (AD) is a common neurodegenerative disease that progressively
impairs memory and cognition. Deposition of amyloid-β (Aβ) peptides is the most important …

[HTML][HTML] Effects of acute and chronic oxidative stress on the blood–brain barrier in 2D and 3D in vitro models

TD Chung, RM Linville, Z Guo, R Ye, R Jha… - Fluids and Barriers of …, 2022 - Springer
Oxidative stress is a shared pathology of neurodegenerative disease and brain injuries, and
is derived from perturbations to normal cell processes by aging or environmental factors …

NRF2 deficiency promotes ferroptosis of astrocytes mediated by oxidative stress in Alzheimer's disease

Z Tang, Z Chen, M Guo, Y Peng, Y Xiao, Z Guan… - Molecular …, 2024 - Springer
Oxidative stress is involved in the pathogenesis of Alzheimer's disease (AD), which is linked
to reactive oxygen species (ROS), lipid peroxidation, and neurotoxicity. Emerging evidence …

The in silico and in vivo evaluation of puerarin against Alzheimer's disease

S Liu, XL Cao, GQ Liu, T Zhou, XL Yang, BX Ma - Food & function, 2019 - pubs.rsc.org
The root of Pueraria lobata has been utilized as a food source for thousands of years in
China. Puerarin is the major bioactive and the most abundant secondary metabolite …

[HTML][HTML] Multimodal functional imaging for cancer/tumor microenvironments based on MRI, EPRI, and PET

K Matsumoto, JB Mitchell, MC Krishna - Molecules, 2021 - mdpi.com
Radiation therapy is one of the main modalities to treat cancer/tumor. The response to
radiation therapy, however, can be influenced by physiological and/or pathological …

[HTML][HTML] Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest

GA Santa-Gonzalez, A Gomez-Molina, M Arcos-Burgos… - Redox biology, 2016 - Elsevier
Many environmental and physiological stresses are chronic. Thus, cells are constantly
exposed to diverse types of genotoxic insults that challenge genome stability, including …