Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

Results The evidence supports that there are a number of biologically plausible
mechanisms whereby physical activity can influence cancer risk, and that physical activity is …

Abstract The American Cancer Society (ACS) publishes the Diet and Physical Activity
Guideline to serve as a foundation for its communication, policy, and community strategies …

Multiple studies in humans and animals have demonstrated the profound impact that
exercise can have on the immune system. There is a general consensus that regular bouts …

The first report demonstrating that prolonged endurance exercise promotes oxidative stress
in humans was published more than 4 decades ago. Since this discovery, many ensuing …

Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …

Physical activity has been associated with lower risks of breast and colorectal cancer in
epidemiological studies; however, it is unknown if these associations are causal or …

Age is a primary risk factor for a number of chronic diseases including mobility disability,
cardiovascular disease (CVD), type 2 diabetes (T2D), and cancer. Most physical activity …

Hypoxia-inducible factors (HIFs) and the HIF-dependent cancer hallmarks angiogenesis and
metabolic rewiring are well-established drivers of breast cancer aggressiveness, therapy …

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …