Idalopirdine (Lu AE58054) is a high affinity and selective antagonist for the human serotonin
5-HT 6 receptor (K i 0.83 nM) in phase III development for mild-to-moderate Alzheimer's …

The 5-HT 6 receptor is a promising target for cognitive disorders, in particular for Alzheimer's
disease (AD). The high affinity and selective 5-HT 6 receptor antagonist idalopirdine (Lu …

Exposure to cues previously associated with drug use and the environment can trigger
intense craving and drug-seeking, often leading to relapse in individuals with substance use …

The neurobiological mechanisms underlying the development of post-traumatic stress
disorder (PTSD) remain elusive. One of the hypotheses is the dysfunction of serotonin (5 …

The lateral habenula (LHb) is an important structure involved in various brain functions,
because it controls the activity of dopaminergic and serotonergic systems in the midbrain …

The dorsal raphe nucleus (DRN) contains large populations of serotonergic (5-HT) neurons.
This nucleus receives GABAergic inhibitory afferents from many brain areas and from DRN …

Cognitive impairments in Alzheimer's disease (AD) have been associated with alterations in
neuronal oscillatory activity, of which hippocampal theta and gamma oscillations are …

Dysfunctional memory seems to be a key component of diverse dementias and other
neuropsychiatric disorders; unfortunately, no effective treatment exists for this, probably …

Ovarian hormones, including progesterone (P4) and 17 β-estradiol (E2), have been shown
to affect memory functions; however, the underlying mechanism whereby ovarian hormone …

It is well established that Cronobacter sakazakii infection cause septicemia, necrotizing
enterocolitis and meningitis. In the present study, we tested whether the C. sakazakii …