Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family,
discovered in the cytoplasm of almost all types of mammalian cells, plays a significant role in …

Oxidative stress has been proven to be related to the onset of a large number of health
disorders. This chemical stress is triggered by an excess of free radicals, which are …

Angiogenesis depends on proangiogenic and anti-angiogenic molecules that regulate
endothelial cell proliferation and migration. Well-regulated angiogenesis plays a pivotal role …

Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …

Melatonin is a natural indoleamine produced by the pineal gland that has many functions,
including regulation of the circadian rhythm. Many studies have reported the anticancer …

Choroidal neovascularization (CNV) is an important characteristic of advanced wet age‐
related macular degeneration (AMD) and leads to severe visual impairment among elderly …

In the physiological condition, the skeletal system's bone resorption and formation are in
dynamic balance, called bone homeostasis. However, bone homeostasis is destroyed under …

Angiogenesis is an essential process involved in various physiological, including
placentation, and pathological, including cancer and endometriosis, processes. Melatonin …

Background: Hepatocellular carcinoma (HCC) growth relies on angiogenesis via vascular
endothelial growth factor (VEGF) release. Hypoxia within tumour environment leads to …

Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. In this context, tumor cells have an …