Inherited kidney diseases (IKDs) are among the leading causes of early-onset chronic
kidney disease (CKD) and are responsible for at least 10–15% of cases of kidney …

Fifteen years ago, this journal published a review outlining future options for regenerating
the kidney. At that time, stem cell populations were being identified in multiple tissues, the …

This article is published as part of a supplement sponsored by Kidney Disease: Improving
Global Outcomes (KDIGO). The opinions or views expressed in this supplement are those of …

Background Whole-exome sequencing (WES) increases the diagnostic rate of genetic
kidney disorders, but accessibility, interpretation of results, and costs limit use in daily …

Rationale & Objective The identification of pathogenic variants in genes associated with
chronic kidney disease can provide patients and nephrologists with actionable information …

Methods In this prospective cohort study, we undertook genetic testing in adults with
suspected GKD according to prespecified criteria. Over 7 years, patients were referred from …

Chronic kidney disease (CKD) is a major healthcare issue worldwide. However, the
prevalence of pediatric CKD has never been systematically assessed and consistent …

Background APOL1 genotype has significant effects on kidney disease development and
progression that vary among specific causes of kidney disease, suggesting the presence of …

Background Despite the emergence of diagnostic and clinical utility evidence in nephrology,
publicly funded access to genomic testing is restricted in most health care systems. To …

Chronic kidney disease (CKD) afflicts 15% of adults in the United States, of whom 25% have
a family history. Genetic testing is supportive in identifying and possibly confirming …