Omics applications in nephrology may have relevance in the future to improve clinical care
of kidney disease patients. In a short term, patients will benefit from specific measurement …

Background: Among individuals with high-risk APOL1 genotypes, the lifetime risk of
developing kidney failure is~ 15%, indicating that other genetic variants or non-genetic …

Abstract Purpose of Review The role of genetics in renal disorders is being increasingly
recognized, prompting the need to describe and address barriers to meaningful …

Clinical variant classification of pathogenic versus benign genetic variants remains a pivotal
challenge in clinical genetics. Recently, the proposition of protein language models has …

Introduction Among individuals with high-risk APOL1 genotypes, the lifetime risk of
developing kidney failure is∼ 15%, indicating that other genetic variants or non-genetic …

Kidney diseases affect more than 690 million individuals worldwide and are associated with
significant morbidity and mortality. 1 Hereditary nephropathies are genotypically and …

(Left) Cryoglobulins vary in appearance by EM. The fibrils in the mesangium stained for IgG-
λ in a patient with an IgG-λ cryoglobulin (type I cryoglobulinemia).(Right) In fibronectin …

Introduction Monogenic causes in over 300 kidney-associated genes account for
approximately 12% of end stage kidney disease (ESKD) cases. Advances in sequencing …

Chronic kidney disease (CKD) is considered a major global health problem with high socio-
economic costs: the risk of CKD in individuals with an affected first degree relative has been …

Background: Chronic kidney disease (CKD) is becoming one of the world's most prevalent
no communicable chronic diseases. The World Health Organization projects CKD to …