Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus
Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …
children. Approximately 36% of episodes of status epilepticus do not respond to the current …
[HTML][HTML] Looking for Novelty in an “Old” Receptor: Recent Advances Toward Our Understanding of GABAARs and Their Implications in Receptor Pharmacology
Diverse populations of GABAA receptors (GABAARs) throughout the brain mediate fast
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …
GABAA receptors in epilepsy: Elucidating phenotypic divergence through functional analysis of genetic variants
NL Absalom, SXN Lin, VWY Liao… - Journal of …, 2023 - Wiley Online Library
Normal brain function requires a tightly regulated balance between excitatory and inhibitory
neurotransmissions. γ‐Aminobutyric acid type A (GABAA) receptors represent the major …
neurotransmissions. γ‐Aminobutyric acid type A (GABAA) receptors represent the major …
[HTML][HTML] Diverse actions of astrocytes in GABAergic signaling
M Ishibashi, K Egawa, A Fukuda - International journal of molecular …, 2019 - mdpi.com
An imbalance of excitatory and inhibitory neurotransmission leading to over excitation plays
a crucial role in generating seizures, while enhancing GABAergic mechanisms are critical in …
a crucial role in generating seizures, while enhancing GABAergic mechanisms are critical in …
Rescue therapies for seizure clusters: pharmacology and target of treatments
B Gidal, K Detyniecki - Epilepsia, 2022 - Wiley Online Library
The primary goal of treatment for seizure clusters is cessation of the cluster to avoid
progression to more severe conditions, such as prolonged seizures and status epilepticus …
progression to more severe conditions, such as prolonged seizures and status epilepticus …
[HTML][HTML] Neuroprotective effect of Ziziphi Spinosae Semen on rats with p-chlorophenylalanine-induced insomnia via activation of GABAA receptor
F Xiao, S Shao, H Zhang, G Li, S Piao… - Frontiers in …, 2022 - frontiersin.org
Ziziphus jujuba var. spinosa (Bunge) Hu ex HF. Chow [Rhamnaceae; Ziziphi Spinosae
Semen (ZSS)] has attracted extensive attention as the first choice of traditional Chinese …
Semen (ZSS)] has attracted extensive attention as the first choice of traditional Chinese …
[HTML][HTML] Basal forebrain cholinergic neurons are vulnerable in a mouse model of Down syndrome and their molecular fingerprint is rescued by maternal choline …
MJ Alldred, H Pidikiti, A Heguy, P Roussos… - … : official publication of …, 2023 - ncbi.nlm.nih.gov
Basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of Down syndrome
(DS) and Alzheimer's disease (AD). Current therapeutics in these disorders have been …
(DS) and Alzheimer's disease (AD). Current therapeutics in these disorders have been …
[HTML][HTML] Novel variants and phenotypes widen the phenotypic spectrum of GABRG2-related disorders
J Komulainen-Ebrahim, JM Schreiber, SM Kangas… - Seizure, 2019 - Elsevier
Purpose Next-generation sequencing (NGS) has made genetic testing of patients with
epileptic encephalopathies easier–novel variants are discovered and new phenotypes …
epileptic encephalopathies easier–novel variants are discovered and new phenotypes …
A versatile synthetic affinity probe reveals inhibitory synapse ultrastructure and brain connectivity
V Khayenko, C Schulte, SL Reis… - Angewandte Chemie …, 2022 - Wiley Online Library
Visualization of inhibitory synapses requires protocol tailoring for different sample types and
imaging techniques, and usually relies on genetic manipulation or the use of antibodies that …
imaging techniques, and usually relies on genetic manipulation or the use of antibodies that …