The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

Hypoxia is a common feature of solid tumors that contributes to angiogenesis, invasiveness,
metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor …

Severe hypoxia [oxygen partial pressure (pO2) below 5–10 mmHg] is more frequent in
glioblastoma multiforme (GBM) compared to lower-grade gliomas. Seminal studies in the …

Abstract Purpose In recent years Magnetic Resonance Elastography (MRE) emerged into a
clinically applicable imaging technique. It has been shown that MRE is capable of …

Hypoxia results from an imbalance between oxygen supply and consumption. It is a
common phenomenon in solid malignant tumors such as head and neck cancer. As hypoxic …

The tumor heterogeneity, which leads to individual variations in tumor microenvironments,
causes poor prognoses and limits therapeutic response. Emerging technology such as …

Abstract Background Isocitrate dehydrogenase 1 (IDH1) mutant gliomas are thought to have
distinct metabolic characteristics, including a blunted response to hypoxia and lower …

Purpose: Insufficient control of infiltrative glioblastoma (GBM) cells is a major cause of
treatment failure and tumor recurrence. Hence, detailed insights into pathophysiologic …

Non-invasive, imaging-based examination of glioma biology has received increasing
attention in the past couple of years. To this end, the development and refinement of novel …

Purpose To introduce a new pH‐sensitive and oxygen‐sensitive MRI technique using amine
proton CEST echo spin‐and‐gradient echo (SAGE) EPI (CEST‐SAGE‐EPI). Methods pH …