Malignant tumors have increasing morbidity and high mortality, and their occurrence and
development is a complicate process. The development of sequencing technologies …

Cancer is a profoundly dynamic, heterogeneous and aggressive systemic ailment, with a
coordinated evolution of various types of tumor niches. Hypoxia plays an indispensable role …

Advances in molecular profiling have facilitated generation of large multi-modal datasets
that can potentially reveal critical axes of biological variation underlying complex diseases …

Cancer is a disease that stems from a fundamental liability inherent to multicellular life forms
in which an individual cell is capable of reneging on the interests of the collective organism …

Glioblastoma (GBM) is the most common yet uniformly fatal adult brain cancer. Intra-tumoral
molecular and cellular heterogeneities are major contributory factors to therapeutic …

JCI Insight - Spatial analysis of recurrent glioblastoma reveals perivascular niche
organization Go to The Journal of Clinical Investigation About Editors Consulting Editors For …

Nuclear atypia, including altered nuclear size, contour, and chromatin organization, is
ubiquitous in cancer cells. Atypical primary nuclei and micronuclei can rupture during …

In this issue of Cancer Cell, Zhong et al. explore the dual role of TREM2 in glioblastoma-
associated myeloid cells, demonstrating its function in promoting inflammation at the tumor …

Gliomas are diffusely infiltrating brain tumors whose prognosis is strongly influenced by their
extent of invasion into the surrounding brain tissue. While lower-grade gliomas present more …

Glioblastoma multiforme (GBM) is one of the most lethal brain tumors, characterized by
profound heterogeneity. While single-cell transcriptomic studies have revealed extensive …