The dopamine motive system: implications for drug and food addiction
Behaviours such as eating, copulating, defending oneself or taking addictive drugs begin
with a motivation to initiate the behaviour. Both this motivational drive and the behaviours …
with a motivation to initiate the behaviour. Both this motivational drive and the behaviours …
The role of glucagon‐like peptide 1 (GLP‐1) in addictive disorders
MK Klausen, M Thomsen, G Wortwein… - British Journal of …, 2022 - Wiley Online Library
Drug, alcohol and tobacco use disorders are a global burden affecting millions of people.
Despite decades of research, treatment options are sparse or missing, and relapse rates are …
Despite decades of research, treatment options are sparse or missing, and relapse rates are …
[HTML][HTML] Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial
MK Klausen, ME Jensen, M Møller, N Le Dous… - JCI insight, 2022 - ncbi.nlm.nih.gov
Background Alcohol use disorder (AUD) is a chronic, relapsing brain disorder that accounts
for 5% of deaths annually, and there is an urgent need to develop new targets for …
for 5% of deaths annually, and there is an urgent need to develop new targets for …
[HTML][HTML] Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats
C Aranäs, CE Edvardsson, OT Shevchouk, Q Zhang… - …, 2023 - thelancet.com
Background Glucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …
[HTML][HTML] GLP-1a: going beyond traditional use
LF Laurindo, SM Barbalho, EL Guiguer… - International Journal of …, 2022 - mdpi.com
Glucagon-like peptide-1 (GLP-1) is a human incretin hormone derived from the proglucagon
molecule. GLP-1 receptor agonists are frequently used to treat type 2 diabetes mellitus and …
molecule. GLP-1 receptor agonists are frequently used to treat type 2 diabetes mellitus and …
[HTML][HTML] Semaglutide and Tirzepatide reduce alcohol consumption in individuals with obesity
Abstract Alcohol Use Disorder (AUD) contributes significantly to global mortality. GLP-1
(Glucagon-like peptide-1) and GLP-1/GIP (Glucose-dependent Insulinotropic Polypeptide) …
(Glucagon-like peptide-1) and GLP-1/GIP (Glucose-dependent Insulinotropic Polypeptide) …
[HTML][HTML] Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate …
Objective Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RA) and fibroblast
growth factor-21 (FGF21) confer similar metabolic benefits. GLP-1RA induce FGF21, leading …
growth factor-21 (FGF21) confer similar metabolic benefits. GLP-1RA induce FGF21, leading …
[HTML][HTML] The therapeutic potential of glucagon-like peptide-1 for persons with addictions based on findings from preclinical and clinical studies
E Jerlhag - Frontiers in Pharmacology, 2023 - frontiersin.org
Although the multifaceted mechanisms underlying alcohol use disorder (AUD) have been
partially defined, the neurobiological complexity of this disorder is yet to be unraveled. One …
partially defined, the neurobiological complexity of this disorder is yet to be unraveled. One …
Metabolic hormone action in the VTA: Reward-directed behavior and mechanistic insights
CE Geisler, MR Hayes - Physiology & behavior, 2023 - Elsevier
Dysfunctional signaling in midbrain reward circuits perpetuates diseases characterized by
compulsive overconsumption of rewarding substances such as substance abuse, binge …
compulsive overconsumption of rewarding substances such as substance abuse, binge …
[HTML][HTML] Can GLP-1 be a target for reward system related disorders? A qualitative synthesis and systematic review analysis of studies on palatable food, drugs of …
CY Eren-Yazicioglu, A Yigit, RE Dogruoz… - Frontiers in Behavioral …, 2021 - frontiersin.org
The role of glucagon-like peptide 1 (GLP-1) in insulin-dependent signaling is well-known;
GLP-1 enhances glucose-dependent insulin secretion and lowers blood glucose in …
GLP-1 enhances glucose-dependent insulin secretion and lowers blood glucose in …