Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

Background Monocytes and macrophages express an extensive repertoire of G Protein-
Coupled Receptors (GPCRs) that regulate inflammation and immunity. In this study we …

Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

Hypotrichosis simplex is a group of nonsyndromic human alopecias. We mapped an
autosomal recessive form of this disorder to chromosome 13q14. 11–13q21. 33, and …

Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

We have cloned and expressed a novel human G-protein-coupled receptor closely related
to the human P2Y 12 receptor. It corresponds to the orphan receptor called GPR86. GPR86 …

Background G-protein-coupled receptors (GPCRs) are the largest and most diverse family of
transmembrane receptors. They respond to a wide range of stimuli, including small peptides …

The human P2Y11 receptor is coupled to both the phosphoinositide and the cyclic AMP
pathways. A pharmacological characterization of the recombinant human P2Y11 receptor …

The genetic determinants of hair texture in humans are largely unknown. Several human
syndromes exist in which woolly hair comprises a part of the phenotype; however, simple …