Exposure to per-and polyfluoroalkyl substances and markers of liver injury: a systematic review and meta-analysis

E Costello, S Rock, N Stratakis, SP Eckel… - Environmental …, 2022 - ehp.niehs.nih.gov
Background: Experimental evidence indicates that exposure to certain pollutants is
associated with liver damage. Per-and polyfluoroalkyl substances (PFAS) are persistent …

The contribution of the exposome to the burden of cardiovascular disease

T Münzel, M Sørensen, O Hahad… - Nature Reviews …, 2023 - nature.com
Large epidemiological and health impact assessment studies at the global scale, such as
the Global Burden of Disease project, indicate that chronic non-communicable diseases …

[HTML][HTML] Exposure to perfluoroalkyl substances and risk of hepatocellular carcinoma in a multiethnic cohort

JA Goodrich, D Walker, X Lin, H Wang, T Lim… - JHEP Reports, 2022 - Elsevier
Background & Aims Exposure to poly-and perfluoroalkyl substances (PFAS), a class of
persistent organic pollutants, is ubiquitous. Animal studies suggest that PFAS may increase …

[HTML][HTML] PPARα/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per-and polyfluoroalkyl substances: an integrated approach

W Yang, X Ling, S He, H Cui, Z Yang, H An… - Environment …, 2023 - Elsevier
Background Per-and polyfluoroalkyl substances (PFAS) are persistent and ubiquitous
environmental contaminants with well-documented hepatotoxicity. However, the mechanistic …

[HTML][HTML] Association of per-and polyfluoroalkyl substance exposure with fatty liver disease risk in US adults

X Zhang, L Zhao, A Ducatman, C Deng… - JHEP Reports, 2023 - Elsevier
Background & Aims Per-and polyfluoroalkyl substances (PFAS) are widespread pollutants
with demonstrated hepatotoxicity. Few studies have examined the association between …

[HTML][HTML] Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice

B Attema, AWF Janssen, D Rijkers… - Molecular …, 2022 - Elsevier
Objective Perfluoroalkyl substances (PFAS) are man-made chemicals with demonstrated
endocrine-disrupting properties. Exposure to perfluorooctanoic acid (PFOA) has been linked …

Metabolic signatures of youth exposure to mixtures of per-and polyfluoroalkyl substances: a multi-cohort study

JA Goodrich, DI Walker, J He, X Lin… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Exposure to per-and polyfluoroalkyl substances (PFAS) is ubiquitous and has
been associated with an increased risk of several cardiometabolic diseases. However, the …

[HTML][HTML] The exposome and liver disease-how environmental factors affect liver health

R Barouki, M Samson, EB Blanc, M Colombo… - Journal of …, 2023 - Elsevier
Since the initial development of the exposome concept, much effort has been devoted to the
characterisation of the exposome through analytical, epidemiological, and toxicological …

Effects of In Utero PFOS Exposure on Epigenetics and Metabolism in Mouse Fetal Livers

TC Ho, HT Wan, WK Lee, TKY Lam, X Lin… - Environmental …, 2023 - ACS Publications
Prenatal exposure to perfluorooctanesulfonate (PFOS) increases fetus' metabolic risk;
however, the investigation of the underlying mechanism is limited. In this study, pregnant …

Effects of thiacloprid exposure on microbiota–gut–liver axis: Multiomics mechanistic analysis in Japanese quails

B Han, J Li, S Li, Y Liu, Z Zhang - Journal of Hazardous Materials, 2023 - Elsevier
Neonicotinoid insecticides (NNIs) are the most widely used class of pesticides globally.
However, NNIs may cause adverse health effects, including chronic liver disease, and …