Obstructive sleep apnoea and cardiovascular consequences: pathophysiological mechanisms

C Arnaud, T Bochaton, JL Pépin, E Belaidi - Archives of cardiovascular …, 2020 - Elsevier
Obstructive sleep apnoea syndrome is a growing health concern, affecting nearly one billion
people worldwide; it is an independent cardiovascular risk factor, associated with incident …

[HTML][HTML] An outlook on modern and sustainable approaches to the management of grape pomace by integrating green processes, biotechnologies and advanced …

M Perra, G Bacchetta, A Muntoni, G De Gioannis… - Journal of Functional …, 2022 - Elsevier
Grape pomace is the main solid residue of wine industry, mainly composed of seeds, skins
and stalks, all containing high amounts of valuable phytochemicals. Considering its high …

[HTML][HTML] The role of oxidative stress and hypoxia in renal disease

T Honda, Y Hirakawa, M Nangaku - Kidney research and clinical …, 2019 - ncbi.nlm.nih.gov
Oxygen is required to sustain aerobic organisms. Reactive oxygen species (ROS) are
constantly released during mitochondrial oxygen consumption for energy production. Any …

Sleep apnea and cardiovascular risk in patients with prediabetes and type 2 diabetes

SA Paschou, E Bletsa, K Saltiki, P Kazakou, K Kantreva… - Nutrients, 2022 - mdpi.com
Obstructive sleep apnea (OSA) is a common but largely undiagnosed clinical condition,
which is turning into a serious public health issue. Of note is that its prevalence is gradually …

Bilobalide: A review of its pharmacology, pharmacokinetics, toxicity, and safety

J Lu, L Xie, K Liu, X Zhang, X Wang, X Dai… - Phytotherapy …, 2021 - Wiley Online Library
Bilobalide is a natural sesquiterpene trilactone from Ginkgo biloba leaves. It has good water
solubility and is widely used in food and pharmaceutical fields. In the last decade, a plethora …

[HTML][HTML] Protective effects of Eleutheroside E against high-altitude pulmonary edema by inhibiting NLRP3 inflammasome-mediated pyroptosis

Z Shen, D Huang, N Jia, S Zhao, C Pei, Y Wang… - Biomedicine & …, 2023 - Elsevier
Eleutheroside E (EE) is a primary active component of Acanthopanax senticosus, which has
been reported to inhibit the expression of inflammatory genes, but the underlying …

Targeting the ROS-HIF-1-endothelin axis as a therapeutic approach for the treatment of obstructive sleep apnea-related cardiovascular complications

E Belaidi, J Morand, E Gras, JL Pépin… - Pharmacology & …, 2016 - Elsevier
Obstructive sleep apnea (OSA) is now recognized as an independent and important risk
factor for cardiovascular diseases such as hypertension, coronary heart disease, heart …

ALDH2 (aldehyde dehydrogenase 2) protects against hypoxia-induced pulmonary hypertension

Y Zhao, B Wang, J Zhang, D He, Q Zhang… - … , and vascular biology, 2019 - Am Heart Assoc
Objective: Hypoxia-induced pulmonary hypertension (HPH) increases lipid peroxidation with
generation of toxic aldehydes that are metabolized by detoxifying enzymes, including …

Oxidative stress, kinase activation, and inflammatory pathways involved in effects on smooth muscle cells during pulmonary artery hypertension under hypobaric …

P Siques, E Pena, J Brito, S El Alam - Frontiers in physiology, 2021 - frontiersin.org
High-altitude exposure results in hypobaric hypoxia, which affects organisms by activating
several mechanisms at the physiological, cellular, and molecular levels and triggering the …

Antioxidants: An approach for restricting oxidative stress induced neurodegeneration in Alzheimer's disease

S Dubey, E Singh - Inflammopharmacology, 2023 - Springer
Alzheimer's disease (AD) is the leading cause of dementia, affecting millions of people
worldwide. Oxidative stress contributes towards induction of neurodegeneration. It is one of …