Bromelain is a major sulfhydryl proteolytic enzyme found in pineapple plants, having
multiple activities in many areas of medicine. Due to its low toxicity, high efficiency, high …

Pineapple has been used as part of traditional folk medicine since ancient times and it
continues to be present in various herbal preparations. Bromelain is a complex mixture of …

It is well admitted that the link between chronic inflammation and cancer involves cytokines
and mediators of inflammatory pathways, which act during the different steps of …

NF-κB, a transcription factor first discovered in 1986, is now known to be closely connected
to the process of tumorogenesis based on a multiplicity of evidence.(1) NF-κB is activated in …

Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …

Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic
substance with multiple beneficial effects for human health such as anti-inflammatory …

Natural products with immunomodulatory activity are widely used in treatment of many
diseases including autoimmune diseases, inflammatory disorders in addition to cancer …

The interest in South American native plant species has been growing in recent years due to
their health benefits. Brazil is one of the world's mega-diverse locations with over 40,000 …

Four triterpene acetates, α-amyrin acetate (1a), β-amyrin acetate (2a), lupeol acetate (3a),
and butyrospermol acetate (4a), and four triterpene cinnamates, α-amyrin cinnamate (1c), β …