Scope Colorectal cancer is an important health problem across the world. Here, we
investigated the possible antiproliferative/proapoptotic effects of bromelain (from the …

Commercially available bromelain is prepared by performing a tedious and costly
purification method that yields bromelain at different degrees of purity. In the current study, a …

Recently the rise in noncommunicable diseases and side effects of drugs has promoted the
research in food components with biologically active molecules. These bioactive …

Naturally occurring lycopene has been reported for its chemopreventive and
chemotherapeutic efficiency in various cancers, but its exceptional lipophilicity, poor …

Background Bromelain is a pineapple stem extract with a variety of therapeutic benefits
arising from interaction with a number of different biological processes. Several preclinical …

Background Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing
compounds with good safety profiles which have been investigated for their benefits and …

Current systemic dosages of chemotherapeutic drugs such as gemcitabine, 5-FU, cisplatin,
doxorubicin are administered every 7 days over 4 cycles due to systemic toxicity. An …

Cholangiocarcinoma (CC) worldwide is the most common biliary malignancy with poor
prognostic value and new systemic treatments are desirable. Plant extracts like bromelain …

Bromelain is a mixture of proteolytic enzymes that is capable of hydrolyzing glycosidic
linkages in glycoprotein. Glycoprotein's are ubiquitously distributed throughout the body and …

The natural anti-cancer agent bromelain is found to be beneficial for either single or multi-
targeted therapy in gastric and skin carcinoma, by inhibiting cancer cell growth. Importantly …