Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having
an essential role in information transmission throughout the nervous system. Hundreds of …

In the mammalian brain, glutamate is regarded to be the primary excitatory neurotransmitter
due to its widespread distribution and wide range of metabolic functions. Glutamate plays …

Although it is well established that Huntington's disease (HD) is mainly caused by
polyglutamine-expanded mutant huntingtin (mHTT), the molecular mechanism of mHTT …

Triggering receptor expressed on myeloid cells 2 (Trem2) is a myeloid cell-specific gene
expressed in brain microglia, with variants that are associated with neurodegenerative …

About 280 million people suffer from depression as the most common neurological disorder
and the most common cause of death worldwide. Exercise with serotonin released in the …

Context Observational studies indicated obesity and glutamatergic dysfunction as potential
risk factors of depression, and reported disturbance of glutamine metabolism in obese state …

Over 300 million people worldwide suffer from major depressive disorder (MDD).
Unfortunately, only 30–40% of patients with MDD achieve complete remission after …

Dementia is reported to be common in those with type 2 diabetes mellitus. Type 2 diabetes
contributes to common molecular mechanisms and an underlying pathology with dementia …

Post-stroke cognitive impairment, is a major complication of stroke, characterized by
cognitive dysfunction, which directly affects the quality of life. Post-stroke cognitive …

Traumatic brain injury (TBI) is associated with significant cognitive and psychiatric
conditions. Neuropsychiatric symptoms can persist for years following brain injury, causing …